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Clinical Chemistry Exam

For upcoming exam dates and application deadlines, click here.

The ABCC exam is held in conjunction with AACC's Annual Meeting.


Exam parts
The examination in clinical chemistry is comprised of two parts:

  • Part A, biochemical calculations
  • Part B, analytical and clinical issues

Exam domains The examination tests mastery and knowledge of

  • Patient preparation, specimen collection and handling
    Effects of patient variables on test results, specimen collection and safety in handling
  • Analysis
    Chemistry, selection of the method of analysis, method validation, analysis techniques, quality control evaluation, and laboratory safety.
  • Interpretation
    Biochemistry and physiological chemistry, physiology and pathophysiology, clinical significance and usefulness.
  • Laboratory management
    Resource allocation and management, personnel management, computer needs and utilization, quality assurance, and project and process management.

Item taxonomy
The examination tests the candidate's skills in

  • Recall
  • Applied Skills

Item format
All questions are in multiple-choice format.


Part A (3 hours)
The examinee is expected to perform calculations related to:

  • General biochemistry, such as buffer/solution preparations, enzyme kinetics, electrophoresis.
  • Clinical chemistry calculations, such as amylase clearance
  • Basic statistics as applied to clinical chemistry

For Clinical Chemistry Part A sample questions click here

Part B (3.5 hours)
The examination questions encompass:

  • Principles, characteristics and limitations of instrumentation and technologies used in a clinical chemistry laboratory, such as spectrophotometry and chromatography
  • Interpretation of clinical findings and laboratory data, including basic TDM and toxicology
  • Basic pathophysiology
  • Quality control and accounting principles
  • Laboratory safety procedures
  • Sample handling and preparation
  • Interferences

For Clinical Chemistry Part B sample questions click here

Suggested Study Resources for Clinical Chemistry